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. 2014 Aug 19;4(8):e427. doi: 10.1038/tp.2014.69

Figure 2.

Figure 2

Blunted GBR 12909-induced motor activity in BTBR mice. Motor activity induced by 10 mg kg−1 and (a, b) and 20 mg kg−1 (c, d) GBR 12909 in B6 (10 mg kg−1, n=5; 20 mg kg−1, n=6) and BTBR mice (n=6 per dose). Two independent vehicle-treated groups were used to test the effect of 10 mg kg−1 (n=6 per strain) and 20 mg kg−1 GBR 12909 (C57BL/6J, n=5; BTBR, n=6). Locomotion was expressed as distance travelled, measured every 10 min over a 30-min session and presented as time course (a, c) or total activity (b, d). All values are expressed as mean±s.e.m. *P<0.05, compared with vehicle-treated group within strain (one-way analysis of variance).