Table 2. List of the top 10 associated genes from GWAS of BD patients and controls.
Gene | Chr | nSNPs | P | minP |
---|---|---|---|---|
STAB1 | 3 | 71 | 1.9 × 10−4 | 5.5 × 10−7 |
RBM14 | 11 | 23 | 1.0 × 10−2 | 1.0 × 10−4 |
YWHAG | 7 | 70 | 1.2 × 10−2 | 8.3 × 10−4 |
SLPI | 20 | 108 | 1.3 × 10−2 | 8.2 × 10−4 |
HIST1H3H | 6 | 60 | 3.2 × 10−2 | 2.8 × 10−3 |
HNRNPC | 14 | 107 | 3.9 × 10−2 | 1.7 × 10−4 |
PCID2 | 13 | 90 | 4.0 × 10−2 | 1.5 × 10−2 |
CDKN2D | 19 | 47 | 4.0 × 10−2 | 9.8 × 10−4 |
ANKRD36 | 2 | 18 | 4.6 × 10−2 | 8.3 × 10−3 |
CHST14 | 15 | 52 | 5.0 × 10−2 | 2.0 × 10−2 |
Abbreviations: BD, bipolar disorder; Chr, Chromosome; GWAS, genome-wide association study; minP, the original association P-value for the best SNP within the gene; P, the gene-based P-value considering the full set of SNPs; SNP, single-nucleotide polymorphisms.