Figure 2.

Super-axis remediation of complex systemic disorders is shown. Classical neurodegenerative diseases such as Alzheimer’s, Parkinson’s, and Huntington’s disease (AD, PD, and HD) represent intensely complex pathophysiological perturbations of normal systemic biology. These neurodegenerative disorders generate their full phenotypes through the disruption of multiple connected tissue–tissue signaling systems. Therapeutics that can interdict these perturbations at multiple sites in the disease process, i.e., “super-axis” therapeutics (dark blue) possess a much greater capacity to redress the systemic imbalances induced by disease than traditional non-axis therapeutics (light blue) that possess a limited functional repertoire.