Table 3A. Univariate and multivariate Cox proportional hazard analyses of clinicopathologic variables for overall survival rate.

		Univariate analysis			Multivariate analysis
Variable		HR	95% CI	P-value	HR	95% CI	P-value
Age	>50 vs ⩽50 years	1.208	0.776–1.880	0.403	1.005	0.624–1.618	0.984
Sex	Male vs female	2.277	0.560–9.255	0.25	2.03	0.487–8.461	0.331
Stage	III/IV vs I/II	3.023	1.959–4.663	<0.001*	1.961	1.137–3.382	0.016*
Histologic grade	G3 vs G1/G2	1.37	0.760–2.470	0.295	0.91	0.453–1.828	0.792
Lymphovascular invasion	Present vs absent	3.507	2.277–5.400	<0.001*	2.187	1.290–3.709	0.004*
Necrosis	Extensive vs limited/no	1.782	1.153–2.755	0.009*	1.228	0.720–2.095	0.45
LC3B expression	High vs low	1.442	0.953–2.181	0.081	1.091	0.696–1.708	0.705
p62 cytoplasmic expression	High vs low	1.891	1.244–2.876	0.002*	1.441	0.900–2.305	0.128
p62 nuclear expression	Low vs high	2.243	1.402–3.589	0.001*	2.177	1.321–3.586	0.002*

Abbreviations: CI=confidence interval; HR=hazard ratio.