Table 3B. Univariate and multivariate Cox proportional hazard analyses of clinicopathologic variables for disease-specific survival rate.

		Univariate analysis			Multivariate analysis
Variable		HR	95% Confidence interval	P-value	HR	95% Confidence interval	P-value
Age	>50 vs ⩽50 years	1.095	0.645–1.857	0.738	0.876	0.487–1.574	0.657
Sex	Male vs female	3.04	0.421–21.953	0.27	2.077	0.276–15.610	0.478
Stage	III/IV vs I/II	5.624	3.090–10.237	<0.001*	4.105	2.034–8.287	<0.001*
Histologic grade	G3 vs G1/G2	1.415	0.696–2.877	0.338	1.115	0.479–2.598	0.801
Lymphovascular invasion	Present vs absent	4.641	2.780–7.748	<0.001*	2.119	1.177–3.818	0.012*
Necrosis	Extensive vs limited/no	1.651	0.967–2.820	0.066	0.884	0.457–1.709	0.714
LC3B expression	High vs low	1.711	1.033–2.833	0.035*	1.253	0.727–2.158	0.417
p62 cytoplasmic expression	High vs low	2.298	1.368–3.862	0.001*	1.736	0.980–3.076	0.059
p62 nuclear expression	Low vs high	2.545	1.414–4.579	0.002*	2.571	1.356–4.874	0.004*

Abbreviation: HR=hazard ratio