Table 3C. Univariate and multivariate Cox proportional hazard analyses of clinicopathologic variables for recurrence-free survival rate.
| |
|
Univariate analysis |
Multivariate analysis |
||||
|---|---|---|---|---|---|---|---|
| Variable | HR | 95% Confidence interval | P-value | HR | 95% Confidence interval | P-value | |
| Age |
>50 vs ⩽50 years |
0.845 |
0.500–1.427 |
0.528 |
0.817 |
0.470–1.420 |
0.473 |
| Sex |
Male vs female |
1.057 |
0.330–3.384 |
0.925 |
1.151 |
0.349–3.799 |
0.818 |
| Stage |
III/IV vs I/II |
1.711 |
1.024–2.859 |
0.040* |
1.025 |
0.506–2.078 |
0.945 |
| Histologic grade |
G3 vs G1/G2 |
0.852 |
0.365–1.985 |
0.704 |
0.835 |
0.306–2.279 |
0.725 |
| Lymphovascular invasion |
Present vs absent |
2.692 |
1.533–4.727 |
<0.001* |
2.661 |
1.269–5.583 |
0.010* |
| Necrosis |
Extensive vs limited/no |
1.163 |
0.655–2.068 |
0.606 |
1.238 |
0.616–2.489 |
0.549 |
| LC3B expression |
High vs low |
0.886 |
0.521–1.507 |
0.654 |
0.889 |
0.508–1.557 |
0.681 |
| p62 cytoplasmic expression |
High vs low |
0.802 |
0.475–1.354 |
0.408 |
0.745 |
0.415–1.338 |
0.324 |
| p62 nuclear expression | Low vs high | 1.142 | 0.675–1.934 | 0.619 | 1.249 | 0.722–2.163 | 0.427 |
Abbreviation: HR=hazard ratio
*P<0.05.