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. 2014 Aug 13;3(8):e58. doi: 10.1038/emi.2014.61

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M. tuberculosis became resistant to POA when panD expression was induced by ATc. Each strain was printed in triplicate with a replicator at a density of ∼10⁵ CFU/mL. (A) WT/pUV15tetORs-panD^Rv (expressing panD from M. tuberculosis H37Rv) without (− sign) and with (+ sign) ATc, (B) WT/pUV15tetORs-panD^G351A (expressing panD mutant) without and with ATc, (C) WT/pUV15tetORs-panD^T431C (expressing panD mutant) without and with ATc, (D) POA^R 156 (M117I) without and with ATc, (E) WT/pUV15tetORs-panD^MS (expressing panD from M. smegmatis) without and with ATc, (F) WT/pUV15tetORs-panD^EC (expressing panD from E. coli) without and with ATc, (G) WT/pUV15tetORs vector control without and with ATc.