Table 1. panD mutations identified in POA-resistant mutants of M. tuberculosis.
| Strain | Nucleotide change | Amino acid change |
|---|---|---|
| Mycobacterium tuberculosis H37Ra POAR37 | G351A | M117I |
| Mycobacterium tuberculosis H37Ra POAR38 | G351A | M117I |
| Mycobacterium tuberculosis H37Ra POAR48 | G351A | M117I |
| Mycobacterium tuberculosis H37Ra POAR54 | G351A | M117I# |
| Mycobacterium tuberculosis H37Ra POAR55 | G351A | M117I |
| Mycobacterium tuberculosis H37Ra POAR56 | T407G | L136R |
| Mycobacterium tuberculosis H37Ra POAR57 | G351A | M117I |
| Mycobacterium tuberculosis H37Ra POAR59 | G351A | M117I |
| Mycobacterium tuberculosis H37Ra POAR64 | Del 393G | 131codon shift# |
| Mycobacterium tuberculosis H37Ra POAR68 | G351A | M117I |
| Mycobacterium tuberculosis H37Ra POAR71 | G351A | M117I |
| Mycobacterium tuberculosis H37Ra POAR72 | G351A | M117I |
| Mycobacterium tuberculosis H37Ra POAR73 | G351A | M117I |
| Mycobacterium tuberculosis H37Ra POAR76 | G351A | M117I |
| Mycobacterium tuberculosis H37Ra POAR88 | G351A | M117I |
| Mycobacterium tuberculosis H37Ra POAR89 | G351A | M117I |
| Mycobacterium tuberculosis H37Ra POAR90 | G351A | M117I |
| Mycobacterium tuberculosis H37Ra POAR92 | G351A | M117I |
| Mycobacterium tuberculosis H37Ra POAR102 | G351A | M117I |
| Mycobacterium tuberculosis H37Ra POAR106 | G351A | M117I |
| Mycobacterium tuberculosis H37Ra POAR108 | G351A | M117I |
| Mycobacterium tuberculosis H37Ra POAR125 | G351A | M117I |
| Mycobacterium tuberculosis H37Ra POAR126 | G351A | M117I |
| Mycobacterium tuberculosis H37Ra POAR133 | G351A | M117I |
| Mycobacterium tuberculosis H37Ra POAR135 | T413G | V138G |
| Mycobacterium tuberculosis H37Ra POAR136 | G376T | E126* |
| Mycobacterium tuberculosis H37Ra POAR137 | T413A | V138E |
| Mycobacterium tuberculosis H37Ra POAR140 | T413C | V138A# |
| Mycobacterium tuberculosis H37Ra POAR147 | G351A | M117I |
| Mycobacterium tuberculosis H37Ra POAR156 | G351A | M117I |
#
indicates the three POA-resistant mutants that were sequenced by whole-genome sequencing.
*
indicates a stop codon.