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. 2014 Sep 1;6:225. doi: 10.3389/fnagi.2014.00225

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Copyright © 2014 Jasien, Daimon, Wang, Shapiro, Martin and Maudsley.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Identification of coherent regulatory protein signatures in BTBR CNS tissues. Vennplex diagram analysis of the upregulated (BTBR:WT iTRAQ ratio > 1.2) or downregulated (iTRAQ ratio < 0.8) proteins in both the hippocampus and cortex are depicted (A). A small coherently-regulated protein subset across both tissues was evident and comprised a focused protein set strongly linked to human ASD-like conditions (B). Textrous!-based collective processing interrogation of the coherently-regulated BTBR protein set revealed, in the resultant hierarchical word-cloud, a strong potential role of skeletal modeling activity in this protein set (C). This skeletal signaling dependence of ASD was confirmed using the individual processing module of Textrous! (D). In this heatmap output correlation strength between protein and functional term is indicated by the intensity of the teal-colored blocks.