Table 3.

KEGG Pathway analysis for cortical proteins altered in BTBR mice compared to WT controls.

KEGG pathway	C	E	O	R	P	H
Glutathione metabolism	50	2	0.07	27.38	0.0188	47.25356
MTOR signaling pathway	52	2	0.08	26.33	0.0188	45.44142
Arginine and proline metabolism	54	2	0.08	25.35	0.0188	43.7501
Shigellosis	61	2	0.09	22.44	0.0188	38.7279
Renal cell carcinoma	70	2	0.1	19.56	0.0188	33.75747
Chronic myeloid leukemia	73	2	0.11	18.75	0.0188	32.35954
Progesterone-mediated oocyte maturation	86	2	0.13	15.92	0.0188	27.47541
Gap junction	90	2	0.13	15.21	0.0188	26.25006
Melanogenesis	101	2	0.15	13.56	0.0192	23.27844
GnRH signaling pathway	101	2	0.15	13.56	0.0192	23.27844
Oocyte meiosis	112	2	0.16	12.22	0.0192	20.97806
Leukocyte transendothelial migration	116	2	0.17	11.8	0.0192	20.25705
Vascular smooth muscle contraction	116	2	0.17	11.8	0.0192	20.25705
Neurotrophin signaling pathway	127	2	0.19	10.78	0.0192	18.50601
Spliceosome	127	2	0.19	10.78	0.0192	18.50601
Tight junction	132	2	0.19	10.37	0.0192	17.80217
Hepatitis C	134	2	0.2	10.22	0.0192	17.54466
Natural killer cell mediated cytotoxicity	136	2	0.2	10.07	0.0192	17.28716
Insulin signaling pathway	138	2	0.2	9.92	0.0192	17.02965
Alzheimer's disease	167	2	0.24	8.2	0.0261	12.98355
Chemokine signaling pathway	189	2	0.28	7.24	0.0313	10.89226
Metabolic pathways	1130	6	1.65	3.63	0.0188	6.264807

KEGG signaling pathway annotation of the cortical proteins possessing BTBR:WT iTRAQ expression ratios < 1.2 or < 0.8 was created using WebGestalt. Each KEGG pathway significantly populated (p < 0.05) by at least two independent proteins are depicted. For each populated KEGG pathway the number of total proteins in the curated KEGG pathway (C), the number of observed experimental proteins in the KEGG pathway (O), the expected number of proteins in the pathway based on whole-genome background frequency (E), the KEGG pathway enrichment factor (R), the KEGG pathway enrichment probability (P) and the hybrid score (R ^* −log₁₀ P) are indicated (H).