Table 7.
VennPlex Venn diagram analysis of up and downregulated proteins across the cortex and hippocampus of BTBR mice compared to WT controls.
| Protein | Cortex up | Cortex down | Hippo up | Hippo down |
|---|---|---|---|---|
| PRRT2 | 1.951168338 | 2.381953722 | ||
| DYNLL1 | 1.672920918 | 1.737545789 | ||
| DBNL | 1.626693344 | 1.24548243 | ||
| AP3B2 | 1.581785753 | 1.789312776 | ||
| VAT1L | 1.391942674 | 1.401775589 | ||
| WDR33 | 1.379833997 | 2.510567518 | ||
| GOLGA2 | 1.292500223 | 1.60040989 | ||
| LANCL1 | 1.279121599 | 1.320074872 | ||
| ME3 | 1.270939623 | 1.62730561 | ||
| ITSN1 | 1.269638936 | 1.774926636 | ||
| CEP290 | 1.238621608 | 1.454207016 | ||
| PCYOX1L | 1.209317219 | 1.860882083 | ||
| ERMN | −1.243267187 | −1.500264003 | ||
| CSRP1 | −1.365689412 | −1.509867503 | ||
| DBI | −1.496288514 | −2.056916039 | ||
| NUCB1 | −1.631205729 | −3.561025937 | ||
| EIF5A | 1.517756095 | −1.65673365 | ||
| MMAA | 1.391228352 | −1.887879989 | ||
| PTPN11 | 1.247745108 | −3.093767449 | ||
| ZXDB | 1.214676409 | −1.393599577 | ||
| SLC17A7 | 1.204082729 | −1.315805498 | ||
| DPYSL4 | 1.195193712 | −1.314442062 | ||
| OAT | −1.307905257 | 1.362629072 | ||
| Ptcd | 1.828557315 | |||
| PCBP2 | 1.792502849 | |||
| QDPR | 1.7625157 | |||
| SRSF4 | 1.533013648 | |||
| ADCY2 | 1.511246891 | |||
| NDUFS4 | 1.47998035 | |||
| SLC9A3R1 | 1.473396618 | |||
| LETM1 | 1.455678341 | |||
| PRDX3 | 1.44243043 | |||
| IDH2 | 1.441010435 | |||
| EXOC5 | 1.41342868 | |||
| HNRNPUL2 | 1.405691244 | |||
| PTCD1 | 1.371753507 | |||
| DDX5 | 1.365841661 | |||
| PPP1R9B | 1.346708939 | |||
| DPP6 | 1.340020376 | |||
| LAP3 | 1.303333413 | |||
| KCNAB2 | 1.296085587 | |||
| SLC12A5 | 1.252190507 | |||
| HOOK3 | 1.250023514 | |||
| COX5A | 1.247002966 | |||
| WDR1 | 1.244912709 | |||
| GRM2 | 1.243617897 | |||
| CAB39 | 1.2340405 | |||
| RTN3 | 1.233971862 | |||
| TF | 1.233243832 | |||
| FBXO41 | 1.231290747 | |||
| RAB7A | 1.226744118 | |||
| RTN4 | 1.216638369 | |||
| TCP1 | 1.215498024 | |||
| PRKAR2B | 1.215235782 | |||
| CCT3 | 1.20748828 | |||
| PRDM5 | 1.198502382 | |||
| COQ9 | −1.24961385 | |||
| CLDN11 | −1.260614004 | |||
| NCALD | −1.266374541 | |||
| F5 | −1.269955566 | |||
| EXOC6B | −1.275380087 | |||
| CTTN | −1.287911813 | |||
| VBP1 | −1.361766656 | |||
| PICALM | −1.466374966 | |||
| CAPNS1 | −1.756445493 | |||
| TOMM20 | −1.819905488 | |||
| MAPK3 | −1.918813356 | |||
| NUDC | 1.732009523 | |||
| RAP2B | 1.726355193 | |||
| KIF2A | 1.663032474 | |||
| SETDB1 | 1.648556725 | |||
| ATP6V1D | 1.640964877 | |||
| SYNGR1 | 1.58532711 | |||
| DPYSL3 | 1.582802831 | |||
| NCAN | 1.571585688 | |||
| CTNND2 | 1.562506309 | |||
| CNRIP1 | 1.554254382 | |||
| UTP20 | 1.544855143 | |||
| ME1 | 1.478800627 | |||
| PFN1 | 1.477145399 | |||
| PPME1 | 1.455765369 | |||
| APP | 1.455465641 | |||
| LANCL2 | 1.455132031 | |||
| GNAQ | 1.453050806 | |||
| ARPC5L | 1.451224208 | |||
| PRDX2 | 1.448929334 | |||
| CYFIP1 | 1.432347642 | |||
| HSPA2 | 1.431503207 | |||
| SFPQ | 1.427372534 | |||
| TXLNG | 1.42119969 | |||
| GRB2 | 1.4157442 | |||
| CPNE6 | 1.414165286 | |||
| PDXP | 1.410098436 | |||
| GNB2 | 1.408516442 | |||
| GLOD4 | 1.391614359 | |||
| OXR1 | 1.380069445 | |||
| VAMP2 | 1.373709575 | |||
| HSPA1A | 1.373028035 | |||
| HSPA1B | 1.373028035 | |||
| PSD3 | 1.371411227 | |||
| BSG | 1.369172074 | |||
| PFN2 | 1.368469072 | |||
| ATP5J2 | 1.368321641 | |||
| GNB1 | 1.366417736 | |||
| DLG4 | 1.363981591 | |||
| SH3GLB2 | 1.36363306 | |||
| KTN1 | 1.362629072 | |||
| RAB3A | 1.362173026 | |||
| CCT7 | 1.3567651 | |||
| SDHC | 1.347654394 | |||
| BCAN | 1.342898167 | |||
| HSPH1 | 1.337373319 | |||
| ADD2 | 1.336930818 | |||
| AP2A2 | 1.335723865 | |||
| DYNLL2 | 1.322647505 | |||
| GDA | 1.312825433 | |||
| TKT | 1.3105561 | |||
| COX7A2 | 1.308575621 | |||
| SNCA | 1.305570043 | |||
| BAIAP2 | 1.303596608 | |||
| SH3BGRL3 | 1.302583328 | |||
| NPM1 | 1.301978732 | |||
| NIPSNAP1 | 1.299090793 | |||
| ARPC4 | 1.296939524 | |||
| NAPA | 1.292138971 | |||
| CALB1 | 1.290893833 | |||
| CAMKV | 1.286413462 | |||
| COX6C | 1.286388519 | |||
| COX5B | 1.285714649 | |||
| NDUFA9 | 1.285358088 | |||
| ATP6V0D1 | 1.275603048 | |||
| NSFL1C | 1.274526051 | |||
| LDHA | 1.269135901 | |||
| ATP6V1F | 1.266693513 | |||
| CLTB | 1.265664013 | |||
| SRSF4 | 1.261593119 | |||
| LRGUK | 1.260891479 | |||
| NDUFS8 | 1.260447912 | |||
| PPP2CB | 1.259397109 | |||
| COX4I1 | 1.256849924 | |||
| CAMK2D | 1.256848229 | |||
| DNAJC6 | 1.255985647 | |||
| COL6A2 | 1.253698992 | |||
| CRYM | 1.251866833 | |||
| PPP3CA | 1.249125255 | |||
| SLC2A1 | 1.24839376 | |||
| PPFIA3 | 1.244596343 | |||
| CAMK2A | 1.241519397 | |||
| SYP | 1.237859198 | |||
| AP2B1 | 1.237413188 | |||
| USP24 | 1.233820239 | |||
| FABP5 | 1.233314773 | |||
| SEPT9 | 1.226916013 | |||
| EHD1 | 1.226344591 | |||
| CAP2 | 1.223807885 | |||
| SLC25A3 | 1.221941931 | |||
| CAMK2B | 1.22058499 | |||
| PTGES3 | 1.216665914 | |||
| PRDX1 | 1.215985447 | |||
| ATP5I | 1.215521395 | |||
| ATIC | 1.213849668 | |||
| GSTM5 | 1.213704207 | |||
| NDUFS7 | 1.211966939 | |||
| DCLK1 | 1.207992461 | |||
| GPD1L | 1.207286149 | |||
| HNRNPL | 1.205847041 | |||
| NAPB | 1.202833155 | |||
| RTN4 | 1.201798491 | |||
| PCSK1N | −1.245474191 | |||
| WDR7 | −1.245967263 | |||
| MAG | −1.248958157 | |||
| DDB1 | −1.255013637 | |||
| MOBP | −1.256321905 | |||
| GAD2 | −1.26014124 | |||
| INA | −1.265874043 | |||
| TPT1 | −1.268669401 | |||
| IDH3G | −1.270175029 | |||
| PCCB | −1.272883353 | |||
| MAPRE2 | −1.274095945 | |||
| MRPS36 | −1.275342647 | |||
| MARCKS | −1.280485807 | |||
| PSMC6 | −1.281124693 | |||
| ABAT | −1.283265073 | |||
| NTM | −1.284285221 | |||
| CA2 | −1.284359839 | |||
| HPCAL1 | −1.284463003 | |||
| MOG | −1.295178624 | |||
| PSMA6 | −1.297701354 | |||
| SDHA | −1.300775393 | |||
| COPB1 | −1.300938943 | |||
| NONO | −1.301095086 | |||
| TUFM | −1.311237761 | |||
| ADSS | −1.311542644 | |||
| IGSF8 | −1.312784192 | |||
| COX5A | −1.313555144 | |||
| UQCRFS1 | −1.316410553 | |||
| CKB | −1.318123142 | |||
| PIP4K2B | −1.324477494 | |||
| NEFM | −1.330302859 | |||
| PSMD6 | −1.330311752 | |||
| NEFL | −1.344530231 | |||
| NDUFA8 | −1.348309239 | |||
| BIN1 | −1.354260702 | |||
| PTMS | −1.379162453 | |||
| PHB2 | −1.381012946 | |||
| NDUFS2 | −1.382654847 | |||
| DSTN | −1.396469687 | |||
| CCT5 | −1.396711507 | |||
| S100B | −1.403153034 | |||
| CLASP2 | −1.403192685 | |||
| EPB41L1 | −1.419486383 | |||
| PFKL | −1.424253294 | |||
| PSAP | −1.429458675 | |||
| CPLX1 | −1.437904339 | |||
| SERPINA3K | −1.462482626 | |||
| AHSA1 | −1.482509362 | |||
| SET | −1.494218612 | |||
| ATL1 | −1.49652324 | |||
| PRKACB | −1.501341659 | |||
| NME2 | −1.502355851 | |||
| ITPKA | −1.515605888 | |||
| NCS1 | −1.519434163 | |||
| EEF1A1 | −1.528884517 | |||
| PLCB1 | −1.530645112 | |||
| ENPP6 | −1.542384655 | |||
| SYNE1 | −1.544411246 | |||
| PCP4 | −1.554348855 | |||
| MBP | −1.583600552 | |||
| NCEH1 | −1.612308156 | |||
| ACSL6 | −1.612342183 | |||
| GLO1 | −1.659621805 | |||
| PPP1R1B | −1.668571078 | |||
| HSD17B10 | −1.719780931 | |||
| SIRT2 | −1.776727737 | |||
| GPHN | −1.810243901 | |||
| MORC1 | −1.853643692 | |||
| SLC6A11 | −1.877132951 | |||
| PDHX | −1.878732243 | |||
| PTK6 | −1.89800334 | |||
| DPYSL5 | −1.903465278 | |||
| HPRT1 | −2.333095423 |
For each specific protein studied fold change values, indicated in the table below, were generated from the iTRAQ expression ratios of (>1.2 or <0.8) proteins differentially regulated in the BTBR tissues [Cortex, Hippocampus (Hippo)] compared to WT.