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. 2014 Sep 1;27(7):361–366. doi: 10.1089/vim.2014.0045

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Copyright 2014, Mary Ann Liebert, Inc.

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FIG. 3. — Diverting immunodominance promotes enhanced antitumor responses to an H-2K^d restricted HER2/neu epitope. Lymphocytes isolated after infection with VP2 mutagenized TMEV p66 vaccine were analyzed for the presence of CD8+ T-cells specific for the HER2/neu peptide p66. (A) H-2K^d/p66 specific CD8+ T-cells induced with TMEV p66 vaccines encoding VP2-S125A and M130L mutations compared to a vaccine with VP2 wild-type sequence and the nonvaccine strain wild-type TMEV. (B) Assessment of the percentage and absolute number of antigen specific CD8+ T-cells induced with p66 vaccines (*p<0.05 compared to specified or ^ap<0.05 significant compared to all others by ANOVA/Student/Newman–Keuls).