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. 2014 Sep 1;34(9):716–726. doi: 10.1089/jir.2013.0123

FIG. 2.

FIG. 2.

Histopathologic evaluation of Mtb-infected and etanercept treated or untreated rabbit lungs. (A–C) Lungs of infected rabbit at 4 weeks postinfection. Well-organized granulomas (0.5–1.5 mm diameter) with central necrosis, surrounded by macrophages (M) and lymphocyte (L) cuff. (D–F) Lungs of infected untreated rabbit at 12 weeks postinfection. Large coalescent granulomas (about 2 mm diameter), with central necrosis (N) and mineralization, and high numbers of macrophages (M) and lymphocytes (L). (G–I) Lungs of 8 weeks-etanercept-treated (ie, 12 weeks postinfection) rabbit. Much larger lesions (3–4 mm diameter) with extensive necrosis (N) and liquefaction surrounded by PMNs, foamy macrophages (M), and lymphocytic (L) aggregates. (J–L) Etanercept-treated rabbit lung with a cavity (cav) at 8 weeks treatment (ie, 12 weeks postinfection). Note the layers around the cavity lumen: an extensive necrotic zone (N), with numerous PMNs (P) and macrophages (M). H&E stain. Original magnification:×4 (A, D, G, J),×10 (B, E, H),×40 (C, F, I, K, L). H&E, hematoxylin-eosin; PMN, polymorphonuclear.