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. 2014 Sep 1;34(9):716–726. doi: 10.1089/jir.2013.0123

FIG. 3.

FIG. 3.

Genomewide transcriptional analysis of Mtb-infected etanercept-treated rabbit lungs. (A) Venn diagram showing significantly differentially expressed (P<0.05) genes (SDEG) in the etanercept treated, compared to untreated rabbit lungs at 4 and 8 weeks of treatment. (B) Intensity map showing the expression pattern of SDEG in the etanercept-treated rabbits at 4 and 8 weeks of treatment. The percentages in the boxes are derived from the number of up (red) or down (blue) regulated genes versus total number of genes at each time point. The color scale bar ranges from −3 (blue; downregulation) to +3 (red; upregulation). (C) Intensity plot showing the expression level of 15 SDEG involved in etanercept interaction network in the lungs of etanercept treated, compared to untreated rabbits at 4 and 8 weeks of treatment. The color scale bar ranges from −3 (blue; downregulation) to +3 (red; upregulation) and the gradation in color corresponds to respective level of expression. Yellow color denotes no significant change between the untreated and etanercept-treated samples.