Figure 2.

miRNAs involved in angiogenic process. Angiogenesis regulation conducted by different miRNAs is based on a complex network and is summarized in this figure. Red boxes indicate proangiogenic miRNA, green boxes indicate antiangiogenic miRNAs, and dashed circles indicate genes involved in molecular pathway taking place in both tumour and endothelial cells. Grey lines represent inhibitory processes while the blue lines with arrows represent activation processes and the dashed black line represents the ubiquitin-mediated degradation HGS (hepatocyte growth factor-regulated tyrosine kinase substrate), SUFU (suppressor of fused), FUS-1 (FUS RNA binding protein), PIK3C2α (phosphoinositide-3-kinase class 2α), THBS1 (thrombospondin-1), HIF-1α (hypoxia-inducible factor 1 alpha), HIF-1β (hypoxia-inducible factor-1 beta), VEGF (vascular endothelial growth factor), bFGF (basic fibroblast growth factor), Spred-1 (sprouty-related, EVH1 domain containing 1), PIK3R2 (phosphoinositide-3-kinase, regulatory subunit 2), SCF (stem cell factor), c-KIT (tyrosine-protein kinase kit), VEGFR-2 (vascular endothelial growth factor receptor 2), ERK (extracellular signal-regulated kinase), AKT (v-akt murine thymoma viral oncogene homolog 1), PTEN (phosphatase and tensin homolog), Ets-1 (avian erythroblastosis virus E26 (v-ets) oncogene homolog-1), fibroblast growth factor receptor-1 (FGFR-1), GAX (growth arrest homeobox) and HOXA5 (homeobox A5), RAS (v-ki-ras2 kirsten rat sarcoma viral oncogene homolog), RAF-1 (v-raf-1 murine leukemia viral oncogene homolog 1), Cul2 (Cullin 2), mTOR (mechanistic target of rapamycin serine/threonine kinase), and Src (v-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog).