Table 3.
Compound | Mean changes in paw edema (mL) mean ± SEM | % Inhibition | ||||
---|---|---|---|---|---|---|
30 min | 2 hr | 4 hr | 30 min | 2 hr | 4 hr | |
Control | 0.612 ± 0.014 | 0.754 ± 0.051 | 0.621 ± 0.013 | — | — | — |
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Diclofenac sodium | 0.232 ± 0.021 | 0.277 ± 0.019 | 0.277 ± 0.027 | 62.09 ± 0.095 | 63.26 ± 0.095 | 55.39 ± 0.095 |
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3a** | 0.403 ± 0.024 | 0.462 ± 0.026 | 0.384 ± 0.013 | 34.15 ± 0.011 | 38.72 ± 0.010 | 38.16 ± 0.019 |
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3b** | 0.265 ± 0.033 | 0.292 ± 0.05 | 0.256 ± 0.020 | 56.69 ± 0.033 | 61.27 ± 0.050 | 58.77 ± 0.039 |
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3c* | 0.272 ± 0.009 | 0.341 ± 0.041 | 0.290 ± 0.030 | 55.55 ± 0.041 | 54.77 ± 0.023 | 53.30 ± 0.013 |
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3d** | 0.366 ± 0.043 | 0.433 ± 0.009 | 0.371 ± 0.010 | 40.19 ± 0.014 | 42.57 ± 0.063 | 40.25 ± 0.019 |
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3e* | 0.425 ± 0.013 | 0.526 ± 0.019 | 0.437 ± 0.011 | 30.55 ± 0.033 | 30.23 ± 0.011 | 29.62 ± 0.024 |
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3f* | 0.442 ± 0.039 | 0.556 ± 0.103 | 0.463 ± 0.019 | 27.77 ± 0.134 | 26.25 ± 0.028 | 25.44 ± 0.020 |
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3g** | 0.258 ± 0.024 | 0.322 ± 0.09 | 0.271 ± 0.17 | 57.84 ± 0.006 | 57.29 ± 0.008 | 56.36 ± 0.04 |
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3h* | 0.359 ± 0.009 | 0.442 ± 0.009 | 0.369 ± 0.024 | 41.33 ± 0.039 | 41.37 ± 0.020 | 40.57 ± 0.024 |
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3i** | 0.428 ± 0.020 | 0.524 ± 0.024 | 0.453 ± 0.07 | 30.06 ± 0.041 | 30.50 ± 0.09 | 27.05 ± 0.009 |
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3j* | 0.466 ± 0.041 | 0.564 ± 0.061 | 0.471 ± 0.011 | 23.85 ± 0.043 | 25.19 ± 0.041 | 24.15 ± 0.011 |
*P < 0.05 significant from control.
**P < 0.01 significant from control.