Table 2.
Variance in outcome criteria by time and group: proportion, analysis of variance, significance.
| Intervention N=97 |
Control group N=106 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Source of variance | BL | FU | BL | FU | ||||||
| PATIENT | p | |||||||||
| General Practitioner (%) | 90.7 | 55.7 | 74.5 | 45.3 | 0.317 | |||||
| Neurologist (%) | 28.9 | 18.6 | 4.7 | 2.8 | <.001* | |||||
| Psychiatrist / psychotherapist (%) | 11.3 | 3.1 | 17.0 | 8.5 | .083 | |||||
| Casualty (%) | 16.5 | 1.0 | 13.2 | 0.0 | ||||||
| Hospital (%) unscheduled | 29.9 | 5.2 | 26.4 | 3.8 | 0.673 | |||||
| Therapy | ||||||||||
| Ergotherapy (%) | 3.1 | 3.1 | 0.9 | 0 | ||||||
| Vocal therapy (%) | 1.0 | 0 | 1.9 | 0.9 | ||||||
| Day care (%) | 0 | 1.0 | 3.8 | 3.8 | ||||||
| Antidementive Therapy (%) | 34.0 | 50.5 | 34.0 | 35.8 | .035* | |||||
| Donepezil (%) | 2.1 | 5.2 | 4.7 | 5.7 | ||||||
| Rivastigmine (%) | 4.1 | 6.2 | 2.8 | 2.8 | ||||||
| Galantamine (%) | 9.3 | 15.5 | 13.2 | 7.5 | ||||||
| Memantine (%) | 20.6 | 25.8 | 17.9 | 19.8 | ||||||
| Effects by ANOVA | ||||||||||
| BL | FU | BL | FU | Group F (p) |
Time F (p) |
Group*Time F(p) | ||||
| NAA, mean (SD) | 37.0 (6.6) | 37.9 (8.2) | 36.7 (7.0) | 37.4 (7.6) | 0.26 (0.611) | 0.04 (0.835) | ||||
| IADL, mean (SD) | 2.7 (2.1) | 2.3 (2.0) | 2.9 (2.3) | 2.4 (2.1) | 0.74 (0.390) | 0.41 (0.521) | ||||
| MMSE, mean (SD) | 19.1 (6.0) | 18.4 (6.3) | 19.3 (6.3) | 17.9 (6.3) | 0.003 (0.956) | 1.44 (0.232) | ||||
| EQ-5D, VAS, mean (SD) | 55.6 (17.9) | 59.2 (17.5) | 60.1 (19.9) | 60.3 (22.6) | 1.32 (0.252) | 1.14 (.287) | ||||
| Qol-AD, mean (SD) | 33.6 (4.9) | 33.9 (5.6) | 33.0 (4.8) | 33.7 (5.7) | 0.65 (0.423) | 1.57 (0.211) | 0.32 (.572) | |||
| CAREGIVER | ||||||||||
| Hours per day, mean (SD) | 8.5 (8.6) | 10.3 (9.5) | 6.4 (6.3) | 10.5 (9.9) | 0.14 (0.712) | 2.84 (0.095) | 1.77 (0.187) | |||
| EQ-5D, VAS, mean (SD) | 72.8 (18.6) | 70.9 (18.9) | 70.7 (18.9) | 70.4 (18.9) | 0.69 (0.407) | 0.12 (0.734) | 0.32 (0.963) | |||
| SF-36 health survey | ||||||||||
| Physical health sum score, mean (SD) | 48.0 (11.2) | 46.5 (11.6) | 46.2 (12.7) | 43.9 (13.2) | 1.61 (0.207) | 0.12 (0.912) | 0.38 (0.536) | |||
| Mental health sum score, mean (SD) | 47.9 (13.5) | 52.4 (10.1) | 50.4 (10.8) | 52.3 (10.0) | 4.01 (0.047)* | 0.31 (0.577) | 2.26 (0.134) | |||
*
p<0.05; intra-group comparison: McNemar-test, inter-group comparison: chi-squaretest,
BL= Baseline, FU= Follow up; NAA= Nuremberg Altersinventar; IADL= Lawtons instrumental activities of daily life VAS= Visual Analog Scale.