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. Author manuscript; available in PMC: 2014 Sep 1.
Published in final edited form as: Am J Hematol. 2013 Sep 30;89(1):19–24. doi: 10.1002/ajh.23568

Table 4.

Treatment Delivery

Dose Level
Level 1
(30 + 30)
Level 2
(30 + 50)
Level 3
(50 + 50)
All

Disposition During Treatment

  No. registered 13 19 14 46

  No. evaluable for toxicity 11 12 12 35

Diagnosis , no.
  Indolent B-Cell NHL 3 3 6 12
  Intermediate Grade B-NHL 2 3 6 11
  Mantle Cell Lymphoma 3 3 0 6
  T/NK-Cell NHL 3 3 0 6

  Median Cycles Received (range) 3 (1–6) 2 (0–6) 2 (0–6) 2 (0–6)

  Median doses received (range) 12 (4–24) 8 (2–24) 8 (3–24) 8 (2–24)

Reason for Discontinuing Therapy

  Completed all planned therapy 3 (27) 1 (8) 1 (8) 5 (14)

  Adverse Event 0 (0) 2 (17) 3 (25) 5 (14)

  Disease Progression 6 (55) 7 (58) 7 (58) 20 (57)

  Death 0 (0) 1 (8) 0 (0) 1 (3)

  Proceeded to transplant 0 (0) 1 (8) 0 (0) 1 (3)

  Other 2 (18) 0 (0) 1 (8) 3 (9)