Table 4.
Dose Level |
||||
---|---|---|---|---|
Level 1 (30 + 30) |
Level 2 (30 + 50) |
Level 3 (50 + 50) |
All | |
Disposition During Treatment | ||||
No. registered | 13 | 19 | 14 | 46 |
No. evaluable for toxicity | 11 | 12 | 12 | 35 |
Diagnosis , no. | ||||
Indolent B-Cell NHL | 3 | 3 | 6 | 12 |
Intermediate Grade B-NHL | 2 | 3 | 6 | 11 |
Mantle Cell Lymphoma | 3 | 3 | 0 | 6 |
T/NK-Cell NHL | 3 | 3 | 0 | 6 |
Median Cycles Received (range) | 3 (1–6) | 2 (0–6) | 2 (0–6) | 2 (0–6) |
Median doses received (range) | 12 (4–24) | 8 (2–24) | 8 (3–24) | 8 (2–24) |
Reason for Discontinuing Therapy | ||||
Completed all planned therapy | 3 (27) | 1 (8) | 1 (8) | 5 (14) |
Adverse Event | 0 (0) | 2 (17) | 3 (25) | 5 (14) |
Disease Progression | 6 (55) | 7 (58) | 7 (58) | 20 (57) |
Death | 0 (0) | 1 (8) | 0 (0) | 1 (3) |
Proceeded to transplant | 0 (0) | 1 (8) | 0 (0) | 1 (3) |
Other | 2 (18) | 0 (0) | 1 (8) | 3 (9) |