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. Author manuscript; available in PMC: 2015 Jul 31.
Published in final edited form as: Cell. 2014 Jul 24;158(3):481–491. doi: 10.1016/j.cell.2014.06.022

Figure 4. Neutralization activity of the CH235 clonal lineage antibodies against autologous CH505 viruses.

Figure 4

Heatmap analysis of neutralization data generated from 41 pseudoviruses (row) and 10 CH235 lineage mAbs (column). The neutralization potency (IC50) is shown in different shades of colors as indicated in the histogram; from white (>50 µg/ml) to dark red (0.1 µg/ml) (see also Table S4). The CH505 T/F and select variant Env pseudoviruses from each time time point (weeks 4-100) were assayed against the unmutated common ancestor (UCA), intermediate antibodies (IA4-1) and mature autologous neutralizing antibodies (CH235, CH236, CH239, CH240 and CH241) in the TZM-bl cell-based neutralization assay. The partially and fully resistant viruses are indicated by the blue bracket. See also Figure S5 and Table S4.