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. Author manuscript; available in PMC: 2015 Jul 31.
Published in final edited form as: Cell. 2014 Jul 24;158(3):481–491. doi: 10.1016/j.cell.2014.06.022

Figure 7. Schema of Cooperation of B Cell Lineages in Induction of HIV-1 Broadly Neutralizing Antibodies.

Figure 7

The T/F Env (red Env trimer) likely initiated both the CH235 and CH103 lineages by binding to their UCA. The CH235 lineage (dark blue), selected viral escape mutations in loop D of the CH505 T/F virus (blue Env timer) at week 53. The CH103 lineage gradually accumulated mutations that led to acquisition of bnAb activity as CH103 lineage affinity maturation progressed. The loop D mutant Envs more avidly bound CH103 IAs and mature antibodies than the T/F Env and thus cooperated with the T/F Env to drive CH103 bnAb B cell lineage development.