Table 4.
Genome-wide significant variants associated with GDF-15 in FHS and PIVUS*
| Chr | SNP | Position (NCBI 36.3) |
Location Relative to gene |
Nearest gene(s) |
Allele (major/ minor) |
MAF | FHS P |
PIVUS P |
Meta- analysis P |
|---|---|---|---|---|---|---|---|---|---|
| 19 | rs888663 | 18345922 | downstream | PGPEP1 | T/G | 0.19 | 2.54E-24 | 1.01E-03 | 2.74E-32 |
| 19 | rs3746181 | 18338017 | 3' UTR | PGPEP1 | G/A | 0.19 | 7.61E-24 | 4.08E-04 | 6.22E-32 |
| 19 | rs1363120 | 18343304 | downstream | PGPEP1 | G/C | 0.19 | 6.82E-24 | 9.23E-04 | 1.50E-31 |
| 19 | rs749451 | 18340647 | 3' UTR | PGPEP1 | C/T | 0.43 | 8.09E-25 | 5.17E-02 | 1.21E-29 |
| 19 | rs1054564 | 18360815 | 3' UTR | GDF15 | G/C | 0.14 | 7.98E-15 | 2.49E-13 | 8.17E-28 |
| 19 | rs1227731 | 18358903 | intronic | GDF15 | G/A | 0.14 | 8.57E-15 | 2.53E-13 | 8.22E-28 |
| 19 | rs3195944 | 18337711 | 3' UTR | PGPEP1 | A/G | 0.13 | 2.28E-14 | 2.24E-09 | 6.16E-25 |
| 19 | rs17725099 | 18343358 | downstream | PGPEP1 | G/A | 0.24 | 2.59E-13 | 1.74E-01 | 1.91E-11 |
| 19 | rs1043063 | 18341171 | 3' UTR | PGPEP1 | C/T | 0.35 | 4.58E-09 | 4.29E-01 | 3.12E-06 |
*
See Supplemental Data Table 2 for estimated coefficients/standard errors, Supplemental Data Table 3 for pairwise linkage disequilibrium between SNPs, Supplemental Data Figure 1 for quantile-quantile plot, and Supplemental Data Figure 2 for Manhattan plot of the genome-wide association study.
MAF indicates minor allele frequency; FHS, Framingham Heart Study; PIVUS, Prospective Investigation of the Vasculature in Uppsala Seniors study; UTR, untranslated region; PGPEP1, pyroglutamyl peptidase-I;