Table 4.

Antimalarial activity of binary and ternary lyophilized complexes of artesunate in P. berghei infected mice.

Sl. no.	Groups	Treatment	Mean % parasitemia ⁎ on day 8th PI	% Survivality (n=6, t=30 days)
1	Control group	0.5% CMC solution	49.23±12.34	0
2	Standard group	Artesunate ∼(6 mg/kg)	8.48±3.21	16.7
3	Test group 1	As−β-CD ∼(6 mg/kg of artesunate)	6.25±6.82	50
4	Test group 2	As–HP-β-CD ∼(6 mg/kg of artesunate )	4.27±9.43	67.7
5	Test group 3	As–Me-β-CD ∼(6 mg/kg of artesunate )	0.002±0.0016	100
6	Test group 4	As–β-CD–PEG ∼(6 mg/kg of artesunate)	1.025±1.04	83.3

t=no. of days.

n=no. of animals per group.

PI=post inoculation.

As–β-CD=artesunate–β-cyclodextrin complexes.

As–Me-β-CD=artesunate–methyl-β-cyclodextrin complexes.

As–HP-β-CD=artesunate–hydroxypropyl-β-cyclodextrin complexes.

As–β-CD–PEG=artesunate–β-cyclodextrin–PEG complexes.

^⁎Values were expressed as mean±SD (standard deviation).