Table 1.
Ibuprofen powder samples prepared by melt dispersion technique.
| Powder formulation | Aerosil added to Avicela (%) | Ibc:Smcc ratio | Technique used | Aerosil in final mix (%) |
|---|---|---|---|---|
| Ibc | – | Crystalline ibuprofen alone | – | – |
| Ibsmp10b | 10 (Smcc10) | 1:1 | Physical mixture | 5.0 |
| Ibsmd1c | 1 (Smcc1) | 1:1 | Melt dispersion | 0.5 |
| Ibsmd2c | 2 (Smcc2) | 1:1 | Melt dispersion | 1.0 |
| Ibsmd5c | 5 (Smcc5) | 1:1 | Melt dispersion | 2.5 |
| Ibsmd10c | 10 (Smcc10) | 1:1 | Melt dispersion | 5.0 |
a
Lubrication was done by physical mixing of Aerosil with Avicel (mcc) in a mortar with spatula before use and named as Smcc.
b
Prepared by blending crystalline ibuprofen and Smcc in a mortar with spatula and not crushed.
c
Kneaded mass was prepared after incorporating Smcc into the completely melted ibuprofen (Ibc) at ∼80 °C and cooled to laboratory ambient temperature and passed through mesh 30.