Table 1.
Patient Characteristics
| Overall | Normal | High Risk | t=(11;14) | P-value | ||||||
|---|---|---|---|---|---|---|---|---|---|---|
| N=993 | N=869 | N=97 | N=27 | N vs. HR | N vs. t(11;14) | |||||
| Sex -no. (%) | ||||||||||
| M | 564 | (57) | 494 | (57) | 55 | (57) | 15 | (56) | 0.9 | 0.9 |
| F | 429 | (43) | 375 | (43) | 42 | (43) | 12 | (44) | ||
| Age - yr | ||||||||||
| Median | 58 | 57 | 58 | 59 | ||||||
| (Range) | (29–80) | (29–80) | (31–75) | (44–72) | ||||||
| Age>65 - no. (%) | ||||||||||
| <=65 | 820 | (83) | 721 | (83) | 77 | (79) | 22 | (81) | 0.4 | 0.5 |
| >65 | 173 | (17) | 148 | (17) | 20 | (21) | 5 | (19) | ||
| Year of Auto-HCT - no. (%) | ||||||||||
| <=2005 | 421 | (42) | 374 | (43) | 41 | (42) | 6 | (22) | 0.9 | 0.02 |
| >2005 | 572 | (58) | 495 | (57) | 56 | (58) | 21 | (78) | ||
| Diagnosis to Auto-HCT - (months) | ||||||||||
| Median | 7.8 | 7.9 | 7.7 | 6.6 | ||||||
| (Range) | (1.7–262.8) | (1.7–262.8) | (2.1–65.7) | (3.3–60.5) | ||||||
| <=6 m | 330 | (33) | 287 | (33) | 34 | (35) | 9 | (33) | 0.7 | 0.6 |
| >6 m | 662 | (67) | 581 | (67) | 63 | (65) | 18 | (67) | ||
| Unknown | 1 | 1 | ||||||||
| Prior Auto-HCT - no. (%) | ||||||||||
| 0 | 950 | (96) | 832 | (96) | 92 | (95) | 26 | (96) | 0.4 | 0.7 |
| 1 | 41 | (4) | 35 | (4) | 5 | (5) | 1 | (4) | ||
| 2 | 1 | (0) | 1 | (0) | 0 | (0) | 0 | (0) | ||
| Unknown | 1 | 1 | ||||||||
| B2 M at diagnosis- no. (%) | ||||||||||
| Median | 3.3 | 3.07 | 4.9 | 5.1 | ||||||
| (Range) | (0.5–40) | (0.5–40) | (2–33.1) | (1.4–21.2) | ||||||
| <=3.5 | 373 | (56) | 345 | (59) | 22 | (34) | 6 | (27) | ||
| 3.5–5.5 | 130 | (19) | 109 | (19) | 15 | (23) | 6 | (27) | ||
| >5.5 | 167 | (25) | 129 | (22) | 28 | (43) | 10 | (45) | ||
| Unknown | 323 | 286 | 32 | 5 | ||||||
| B2 M at Auto-HCT- no. (%) | ||||||||||
| Median | 2.6 | 2.6 | 3 | 2.7 | ||||||
| (Range) | (1.2–40) | (1.2–40) | (1.6–23.2) | (1.5–6.9) | ||||||
| <=3.5 | 688 | (75) | 606 | (76) | 62 | (67) | 20 | (80) | 0.05 | 0.4 |
| 3.5–5.5 | 141 | (15) | 124 | (16) | 14 | (15) | 3 | (12) | ||
| >5.5 | 86 | (9) | 67 | (8) | 17 | (18) | 2 | (8) | ||
| Unknown | 78 | 72 | 4 | 2 | ||||||
| Disease Status at Auto-HCT - no. (%) | ||||||||||
| Relapse | 148 | (15) | 110 | (13) | 36 | (37) | 2 | (7) | <0.001 | 0.3 |
| Other | 845 | (85) | 759 | (87) | 61 | (63) | 25 | (93) | ||
| Response prior to Auto-HCT - no. (%) | ||||||||||
| CR/VGPR/PR | 805 | (81) | 711 | (82) | 69 | (71) | 25 | (93) | ||
| MR/SD/PD/NR | 181 | (18) | 151 | (17) | 28 | (29) | 2 | (7) | 0.007 | 0.1 |
| NE | 7 | (1) | 7 | (1) | 0 | (0) | 0 | (0) | ||
| Stem Cell Source- no. (%) | ||||||||||
| BM | 3 | (0) | 2 | (0) | 0 | (0) | 1 | (4) | 0.8 | 0.09 |
| PB | 990 | (100) | 867 | (100) | 97 | (100) | 26 | (96) | ||
| Melphalan Alone- no. (%) | ||||||||||
| Yes | 824 | (83) | 720 | (83) | 80 | (82) | 24 | (89) | 0.9 | 0.3 |
| No | 169 | (17) | 149 | (17) | 17 | (18) | 3 | (11) | ||
| Novel Agent - no. (%) | ||||||||||
| Yes | 668 | (67) | 573 | (66) | 74 | (76) | 21 | (78) | 0.04 | 0.2 |
| No | 325 | (33) | 296 | (34) | 23 | (24) | 6 | (22) | ||