Fig. 1.

Effect of BDNF Val66Met on adolescent suppression of contextual fear. (a) Schematic representation of behavioral paradigm. (b) Mice were fear conditioned with three tone-shock pairings. Twenty-four hours or two weeks after fear conditioning, mice were placed back in the conditioning chamber and after a 2 min acclimation period contextual fear expression was measured as time spent freezing. All results are presented as a mean ± SEM determined from analysis of 7–14 mice per group. * P < 0.001.