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. 2014 Jul 23;42(15):10050–10060. doi: 10.1093/nar/gku662

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© The Author(s) 2014. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 1. — Structures of miRNA duplexes used in this study. (A) Three types of miR-376a-2 duplex and its derivatives. A-type miR-376a-2 duplex is the wild-type duplex formed between miR-376a-2–5p and miR-376a-3p-A, in which the possible editing site of adenosine is situated at position +6 from the 5′ end. I-type or G-type miR-376a-2 duplex is composed of miR-376a-2–5p and miR-376a-3p-I or miR-376a-3p-G. (B) Three types of miR-22 duplex and its derivatives. A-type miR-22 duplex is the wild-type duplex formed between miR-22–5p and miR-22–3p-A, in which the possible editing site of adenosine is situated at position +2. I-type or G-type miR-22 duplex is composed of miR-22–5p and miR-22–3p-I or miR-22–3p-G. (C) Three types of miR-191 duplex and its derivatives. A-type miR-191 duplex is the wild-type duplex formed between miR-191–3p and miR-191–5p-A, in which adenosine is situated at position +3. I-type or G-type miR-191 duplexes are composed of miR-191–3p and either miR-191–5p-I or miR-191–5p-G, respectively.