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Intronic snoRNA processing model. (A) Intronic snoRNAs displaying canonical features including a strong k-turn and/or proximity to the downstream exon are more likely to follow the canonical processing pathway including dependency on core box C/D snoRNP proteins such as NOP58. (B) In contrast, snoRNAs displaying non-canonical features are more likely to depend on non-canonical snoRNA binding proteins such as RBFOX2.
