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. 2014 Jul 23;42(15):9854–9861. doi: 10.1093/nar/gku667

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© The Author(s) 2014. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 3. — Spatial proximity between inter-chromosomal gene pairs from the same functional group. The cumulative distribution function (cdf) of inter-chromosomal proximity between genes from the same group was computed for real and randomized genomes. The plot shows each cdf divided by the cdf of the real genome. As a result the real genome curve has a constant y-value of 1. Red: real genome, blue: average over 10⁵ random genomes. The light blue bands show ±1 standard deviation. (a) PPIs; (b) Complexes; (c) Pathways. The x-axis units are 1 minus the correlation between the normalized Hi-C contact profiles of the regions containing the gene pairs, so that smaller values reflect higher correlation and shorter distances.