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. 2014 Jul 29;42(15):9656–9665. doi: 10.1093/nar/gku680

Figure 6.

Figure 6.

Model of how Pot1 binding modulates 3′ end accessibility. (A) The electrostatic surface representation of Pot1pC shows an electropositive patch (within the black circle) that may be involved in binding the 3′ end of 12mer (PDB ID: 4HIK). Electrostatic potentials were created using the APBS plug-in in PyMOL with electrostatic potential bounds of 2 ±kT/e (49–51). (B) Pot1-DBD can adopt multiple binding modes that may be important for function. Pot1-DBD binds 15mer as a homogeneous 1:1 complex with an occluded 3′ end. Upon disruption of this binding mode, the complex switches to the 12mer-binding mode, which allows the formation of higher order complexes in vitro and may allow telomerase access in vivo.