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. 2014 Jul 24;42(15):9949–9963. doi: 10.1093/nar/gku683

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© The Author(s) 2014. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 6. — Extension of a primer-template containing a thymine–thymine 6–4 photoproduct dimer (6-4pp) (Figure 2D; ZZ = dimer) by Tgo-Pol and Tgo-Pol Z1. (A1) and (A2) Products seen using the primer that initiates synthesis immediately before the lesion with all four dNTPs (A1) or a single dNTP (A2). (B1) and (B2) Products observed with the primer that begins synthesis at the first (3′) base in the 6–4 photoproduct dimer, with the last (3′) base in the primer being either dC (B1) or dA (B2). (C) Products produced with the primer that commences polymerisation at the second (5′) base of the lesion. (D) Products seen using the primer that begins synthesis at the standard dC base that immediately follows the lesion.