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. 2014 Aug 4;42(15):9700–9716. doi: 10.1093/nar/gku697

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© The Author(s) 2014. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 8. — Epigenetic regulation of the CDKN2B locus by EBNA3A. (A) Schematic representation of the CDKN2B promoter region depicting the location of the fragments amplified in the ChIP-qPCR assays. The dark gray box represents the initiator element, the light gray boxes, the first two CDKN2B (p15INK4b) exons. (B and C) Comparative ChIP-qPCR analysis between LCLs transformed with either wt EBV or ΔEBNA3A EBV, quantifying the H3K27me3 (B) or the H3K4me2 (C) across the CDKN2B locus. The level of immunoprecipitated chromatin is expressed as a percentage of the input chromatin. Primers that amplify the promoter of inactive myoglobin (myo) were used as a control. Experiments were performed twice with two independent chromatin preparations.