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. 2014 Aug 7;42(15):9908–9924. doi: 10.1093/nar/gku705

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© The Author(s) 2014. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Figure 10. — Crosstalk between Arg296/Arg299 methylation and Ser302 phosphorylation results in role switch of hnRNPK in DNA damage response. Frequently occurred methylation of Arg296/Arg299 suppresses the PKCδ-mediated Ser302 phosphorylation, which results in the anti-apoptotic effect of hnRNPK. Alternatively, low level of Arg296/Arg299 methylation promotes the nearby Ser302 phosphorylation and pro-apoptotic effect of hnRNPK after DNA damage.