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. Author manuscript; available in PMC: 2015 Mar 1.
Published in final edited form as: Nat Cell Biol. 2014 Aug 3;16(9):864–875. doi: 10.1038/ncb3013

Figure 8. ZEB1 correlates with CHK1 protein levels and poor clinical outcome in human breast cancer.

Figure 8

(a) Immunohistochemical staining of ZEB1 and CHK1 in representative carcinoma specimens on the NCI breast cancer progression tissue microarrays. Brown staining indicates positive immunoreactivity. Scale bar: 50 μm.

(b) Correlation between ZEB1 and CHK1 protein levels in human breast tumors. Statistical significance was determined by a χ2 test. R is the correlation coefficient.

(c) Kaplan-Meier curves showing the distant relapse-free survival of patients with high or low expression of ZEB1 in their breast tumors. Statistical significance was determined by a log-rank test.

(d) The working model of regulation of radiosensitivity and DDR by ZEB1.