This schematic demonstrates the multitude of mechanisms through which nitric oxide increases or decreases the activation of and prevalence of cancer metastasis. Abbreviations: extracellular matrix (ECM), endothelial leukocyte adhesion molecule 1 (ELAM-1), guanylyl cyclase (GC), human umbilical vascular endothelial cells (HUVECs), Cytokine interleukin-33 (IL-33), mitogen-activated protein kinase (MAPK), matrix metalloproteinase (MMP), Nitric oxide (NO•), protein kinase C (PKC), quercetin (QUER), trans-pterostilbene (t-PTER).