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. 2014 Jul 12;36(4):9685. doi: 10.1007/s11357-014-9685-5

Fig. 6.

Fig. 6

ERK5 mediates NGF- and PC-induced KLF4 expression. PC12 Cells were transfected with siRNA scramble control, siERK5, siERK1 or siERK2 for 24 h before NGF or PC was applied for another 1 or 3 h, respectively. KLF4 mRNA was measured by qPCR (n = 3). siERK5 abolished NGF- or PC-induced KLF4 expression (**p < 0.01 compared to siControl; ## p < 0.01 compared to siControl + NGF or PC). siERK5, siERK1 or siERK2 by themselves had no effect compared to siControl. siERK1 + NGF (or PC) or siERK2 + NGF (or PC) showed no statistical difference compared to siControl + NGF (or PC)