Fig. 7.

Both ERK5 and KLF4 are required for NGF- and PC-induced protection. PC12 Cells were transfected with siControl, siERK5, or siKLF4 for 24 h before NGF or PC was applied for another 24 h. Cells were then stressed with H₂O₂, and assessed for cell viability (n = 4). Both siERK5 and siKLF4 attenuated NGF-induced (a) or PC-induced (b) cell survival. siERK1 or siERK2 had no effect on NGF-induced (c) or PC-induced (d) protection (@: p < 0.05; **, ##, @@: p < 0.01; ***, ###: p < 0.001; ****, ####: p < 0.000)