Table 2.
Input parameters for the Markov decision-analytic model - base case
Parameter | Base case | SE | Distribution | Reference |
---|---|---|---|---|
RR reduction (%) | ||||
Diabetes - men | 2.60 | 0.003 | lognormal | [30] |
Diabetes - women | 2.20 | 0.002 | lognormal | [30] |
CHD - men | 0.94 | 0.001 | lognormal | [31] |
CHD - women | 1.14 | 0.001 | lognormal | [31] |
Stroke - men | 1.20 | 0.001 | lognormal | [32] |
Stroke - women | 1.70 | 0.002 | lognormal | [33] |
Colon cancer - men | 1.04 | 0.001 | lognormal | [34] |
Colon cancer - women | 0.40 | 0.001 | lognormal | [34] |
Cost/year data input (€) 1 | ||||
Diabetes | 3,312 | 331 | gamma | [35] |
CHD first year | 4,386 | 439 | gamma | [36–38] |
CHD subsequent years | 1,183 | 118 | gamma | [36–38] |
Stroke first year | 13,319 | 1,332 | gamma | [36] |
Stroke subsequent years | 4,756 | 476 | gamma | [36] |
Colon cancer | 9,575 | 958 | gamma | [36] |
Intervention cost2 | 35 | 3.50 | gamma | [15] |
Intervention cost3 | 21 | 2.13 | gamma | [15] |
Utilities | ||||
At risk | 0.71 | 0.04 | beta | [40] |
Diabetes | 0.63 | 0.06 | beta | [17] |
CHD 1 | 0.47 | 0.05 | beta | [17] |
CHD 1+ | 0.56 | 0.06 | beta | [17] |
Stroke 1 | 0.50 | 0.05 | beta | [17] |
Stroke 1+ | 0.50 | 0.05 | beta | [17] |
Colon cancer 1 | 0.64 | 0.06 | beta | [17] |
Colon cancer 1+ | 0.64 | 0.06 | beta | [17] |
Dead | 0 |
RR, relative risk; CHD, coronary heart disease.
1expressed in the year 2011 euros; 2intervention cost for the years 1,6,11,16.
3intervention cost for the other years.