FIG. 5.

Lenticular levels of 4-hydroxynonenol (4-HNE) in young female rats where one eye was exposed to UV light while the contralateral eye was covered and served as the nonirradiated control. Rats were pretreated for 3 days with topical multifunctional antioxidant, topical nutraceutical Optixcare EH, or the oral nutraceutical Ocu-GLO administered daily. Lens 4-HNE levels measured 2 days after exposure to UV irradiation were reduced by antioxidant treatments in the order: topical 3% JHX-4>topical Optixcare EH>oral Ocu-GLO. With the exception of topical JHX-4-treated rats, all rats had significantly higher (P<0.01) levels of 4-HNE in the UV-exposed lenses compared with the levels in the contralateral nonirradiated controls. Mean±SEM; n=5–6 rats; *P<0.01 compared with untreated irradiated lenses; #P<0.01 compared with irradiated Ocu-GLO-treated lenses.