Table 2.
Tumor bearing nude mice serum pharmacokinetic parameters comparing free and liposomal ADRs ( n = 3)
| Parameter | Unit | Free ADR | Non-irrad | Irrad |
|---|---|---|---|---|
|
t1/2α |
h |
0.20 ± 0.02 |
0.19 ± 0.04 |
0.21 ± 0.05 |
|
t1/2β |
h |
0.98 ± 0.19 |
3.89 ± 0.79 |
1.57 ± 1.31 |
|
t1/2γ |
h |
9.56 ± 4.06 |
21.13 ± 1.50 |
34.53 ± 2.63 |
| CL |
mL/h |
30.96 ± 5.86 |
8.82 ± 4.54 |
6.63 ± 3.74 |
|
Cmax |
μg/mL |
50.45 ± 5.54 |
54.13 ± 4.34 |
53.04 ± 5.68 |
| AUC0-t |
(μg/mL) · h |
79.97 ± 11.36 |
447.19 ± 54.19 |
713.49 ± 120.51 |
| MRT | h | 6.37 ± 2.15 | 27.54 ± 1.53 | 48.58 ± 4.67 |
t1/2, the elimination half time; CL, clearance; Cmax, the maximum observed concentration in the plasma; AUC, area under the concentration-time curve; MRT, mean residence time.