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. 2014 Sep 1;206(5):619–633. doi: 10.1083/jcb.201405026

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© 2014 Wang et al.

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Figure 5. — Membrane-tethered dorsal UNC-6 orients and stabilizes UNC-40 clustering. Anterior is left; ventral is down. (A) An unc-6 mutant with membrane-tethered UNC-6 (zmp-5 > unc-6::nlg-1 TM::GFP; magenta) expressed in the dorsal uterine cells (asterisks). F-actin (green, arrowhead) within the AC (arrow) was polarized toward the source of UNC-6 (animal shown at the P6.p four-cell stage). (B) A grayscale image shows that the dorsal uterine cells (asterisks) express and localize a zmp-5–driven, membrane-tethered UNC-6 protein at cell membranes. (C) A grayscale image shows apical polarization of F-actin in the AC toward dorsal UNC-6. (D–G) Images show colocalization of UNC-40::mCherry (arrowheads; green; expressed in the AC) and membrane-tethered UNC-6 (magenta; expressed in the dorsal uterine cells; asterisks). Images in E–G are magnifications of the area outlined by the box in D. Bars, 5 µm.