. Author manuscript; available in PMC: 2015 Mar 4.

Published in final edited form as: Mol Biosyst. 2014 Jan 10;10(3):369–374. doi: 10.1039/c3mb70397e

Table 1.

Six human enzymes catalyze the ten-step conversion of phosphoribosyl pyrophosphate to inosine monophosphate.

Step(s)	Gene symbol	Description
1	PPAT	Phosphoribosylpyrophosphate amidotransferase
2,3,5	GART	Trifunctional phosphoribosylglycinamide formyltransferase / phosphoribosylglycinamide synthetase / phosphoribosylaminoimidazole synthetase
4	FGAMS	Phosphoribosylformylglycinamidine synthase
6,7	PAICS	Bifunctional phosphoribosylaminoimidazole carboxylase / phosphoribosylaminoimidazole succinocarboxamide synthetase
8	ADSL	Adenylosuccinate lyase
9,10	ATIC	Bifunctional 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase / IMP cyclohydrolase