Figure 2.

Dysfunction in mouse lungs subjected to ischemia-reperfusion (IR) versus in sham-operated lungs. In these experiments, blood flow to the left lungs of wild-type (Kit ^+/+) C57BL/6 mice was interrupted by hilar ligation for 1 h followed by 4 h of reperfusion, then lung harvest (n = 6). Control mice underwent sham ligation (n = 4). Lung water (A) and extravascular plasma equivalents (B) were determined in the ligated and sham-ligated lungs as parameters of lung injury.