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. 2014 Aug 1;124(9):3767–3780. doi: 10.1172/JCI66603

Figure 1. Esophageal development and Barrett’s esophagus.

Figure 1

(A) In esophageal development, the normal process of epithelial maturation (columnar to stratified squamous) is opposite of what is seen in Barrett’s esophagus, in which the stratified squamous epithelium lining the adult esophagus undergoes columnar metaplasia. (B) Columnar CK8 and squamous CK14 immunohistochemistry in mouse E14.5–E17.5 esophagus and P2 esophagus. Scale bars: 50 μm.