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. 2014 Aug 1;124(9):3767–3780. doi: 10.1172/JCI66603

Figure 3. Foxa2 is an esophageal Hh target gene.

Figure 3

FOXA2 expression is upregulated in ShhTg mouse esophageal epithelium. FOXA2 immunohistochemistry in 3D in vivo transplant cultures made with (A) wild-type or (B) ShhTg esophageal epithelial cells. FOXA2 expression is downregulated in Shh–/– embryos. FOXA2 immunohistochemistry in E14.5 (C) esophagus and trachea and (E) distal foregut and E16.5 (D) proximal foregut and (F) distal foregut. (G and H) Higher magnification images of sections shown in E and F, respectively. Gastrointestinal (G) and respiratory (R) epithelium, cartilage (C), and cystic lung (L) are indicated. Scale bars: 50 μm.