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. 2014 Jul 25;124(9):3713–3724. doi: 10.1172/JCI64628

Figure 3. CBD exerts universal antiinflammatory actions.

Figure 3

(A) TNFA mRNA expression following 24-hour “pro-acne” lipogenic and TLR agonist treatments with or without CBD. *P < 0.05 compared with the corresponding CBD-free treatments. (B) IL1B, IL6, and TNFA mRNA expression following 24-hour LPS treatment with or without CBD. *P < 0.05, **P < 0.01, ***P < 0.001 compared with the corresponding CBD-free treatments. (A and B) Data are presented using the ΔΔCT method; GAPDH-normalized mRNA expression of the vehicle control was set as 1 (solid line). Data are expressed as mean ± SD of 3 independent determinations. Two additional experiments yielded similar results.