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. Author manuscript; available in PMC: 2015 Aug 5.
Published in final edited form as: Cell Metab. 2014 Jul 3;20(2):306–319. doi: 10.1016/j.cmet.2014.06.004

Figure 7. pAkt correlates with histone acetylation levels in human prostate cancer.

Figure 7

(A) Representative images of H3K18ac, H3K9ac, H4K12ac, and pAkt expression detected by immunohistochemistry in Gleason grade 3–5, metastatic (n=25) and non-metastatic (n=24) prostate cancer tumors. (B) H-scores were determined and correlations between marks determined. pAkt expression showed a significant correlation with: H3K18ac levels (r=0.7452, p≤0.0001); H3K9Ac (r=0.6283, p≤0.0001); and H4K12ac (r=0.5276, p≤0.0001). (C) Box plot showing H-scores for H4K12ac, H3K18ac, H3K9ac, and pAkt in prostate cancer tumors in patients who developed PSA failure (Yes) or not (No) (**, p<0.005, *, p<0.05).