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. Author manuscript; available in PMC: 2014 Sep 2.
Published in final edited form as: Eur J Med Chem. 2012 Jun 21;54:647–659. doi: 10.1016/j.ejmech.2012.06.017

Figure 4.

Figure 4

Inhibition of the Activity of WT- and Mutant- PRMT1 by 11. The reaction contained 2 μM H4-20, 5 μM [14C] AdoMet and 4 μM inhibitor. Activities of all PRMT1 mutants were normalized to the same level as that of wt-PRMT1 for clear comparison.