Table III.

Association between bedroom dust allergen exposure in the first year of life with recurrent wheeze in year 3.

		Unadjusted		Adjusted (+ sensitization*)		Adjusted (+ race, gender)		Adjusted (+ race, gender, PSS, ETS)
	n	Odds ratio (95% CI)	P	Odds ratio (95% CI)	p	Odds ratio (95% CI)	p	Odds ratio (95% CI)	P
Exposures (year 1)†
Cat	362	0.75 (0.61 – 0.92)	0.005	0.74 (0.61 – 0.91)	0.004	0.73 (0.60 – 0.90)	0.003	0.71 (0.58 – 0.88)	0.001
Dog	359	1.01 (0.80 – 1.27)	0.97	1.01 (0.80 – 1.27)	0.97	1.04 (0.82 – 1.32)	0.76	1.00 (0.79 – 1.28)	0.98
Cockroach	359	0.60 (0.45 – 0.80)	<0.001	0.59 (0.44 – 0.79)	<0.001	0.61 (0.45 – 0.81)	<0.001	0.59 (0.44 – 0.80)	<0.001
Mouse	366	0.65 (0.52 – 0.82)	<0.001	0.64 (0.50 – 0.81)	<0.001	0.64 (0.51 – 0.81)	<0.001	0.65 (0.51 – 0.82)	<0.001
Dust mite (Der f)	364	0.97 (0.78 – 1.20)	0.78	0.96 (0.77 – 1.19)	0.69	0.95 (0.76 – 1.18)	0.63	0.92 (0.73 – 1.15)	0.45
Model using allergen exposure index‡
Exposure Index (0–9)	356	0.73 (0.64 – 0.83)	<0.001	0.73 (0.64 – 0.83)	<0.001	0.73 (0.64 – 0.84)	<0.001	0.73 (0.64 – 0.83)	<0.001
Allergen exposure index stratified by aeroallergen sensitivity‡
Not sensitive	234	0.73 (0.61 – 0.88)	0.95∫	n/a	n/a	0.73 (0.60 – 0.88)	0.97∫	0.72 (0.60 – 0.88)	0.91∫
Sensitive	122	0.73 (0.61 – 0.88)		n/a	n/a	0.74 (0.61 – 0.89)		0.73 (0.61 – 0.89)

^*Individual exposure models are adjusted for the respective sensitization. The Exposure Index is adjusted for overall aeroallergen sensitization.

^†Odds of recurrent wheeze for each 1-log increase in allergen level.

^‡Odds of recurrent wheeze for a 1-unit increase in the allergen exposure index.

^∫Interaction p-value

PSS=Perceived Stress Scale, ETS=Environmental tobacco smoke.