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. Author manuscript; available in PMC: 2014 Sep 2.
Published in final edited form as: Neuroreport. 2013 Jul 10;24(10):550–554. doi: 10.1097/WNR.0b013e3283621344

Figure 1.

Figure 1

TRPC channel blockers fail to block cholinergic excitation. (a) Average responses (5 trials) to trains of 10 current-evoked action potentials (40 Hz) in baseline conditions (thin black traces), in the presence of bath-applied carbachol (CCh, 10 μM, for 5 minutes; thick black traces), after co-application of CCh with Cd2+ or TRPC channel antagonists (for 10 minutes; thick gray traces), and after 10 to 15 minutes of wash in drug-free aCSF (thin light gray traces). Dashed-lines indicate resting membrane potentials. (b) Comparison of cholinergic ADP amplitudes in CCh alone, and after co-application of TRPC antagonists. The number of neurons tested in each experimental group is indicated below the name of the corresponding antagonist.