Table II. Logistic regression models of predictors of R-CHOP as first-line of treatment in DLBCL patients.
| Univariate model | Multiple variable model | |||||
|---|---|---|---|---|---|---|
|
|
|
|||||
| Factors | Odds Ratio | 95% CI | Odds Ratio | 95% CI | ||
| Age, years | ||||||
| ≤60 | Reference | |||||
| >60 | 0.93 | 0.68 | 1.26 | 0.81 | 0.53 | 1.24 |
| Gender | ||||||
| Female | Reference | |||||
| Male | 0.97 | 0.72 | 1.31 | 0.84 | 0.56 | 1.26 |
| Race | ||||||
| White | Reference | |||||
| Black | 1.20 | 0.83 | 1.74 | 0.91 | 0.55 | 1.52 |
| Other | 1.55 | 0.68 | 3.55 | 1.28 | 0.42 | 3.91 |
| ECOG performance status | ||||||
| 0-1 | Reference | |||||
| ≥2 | 0.59* | 0.40 | 0.88 | 0.55* | 0.33 | 0.93 |
| LDH level | ||||||
| Normal | Reference | |||||
| >ULN | 0.72 | 0.50 | 1.05 | 0.80 | 0.48 | 1.34 |
| Disease stage | ||||||
| I/II | Reference | |||||
| III/IV | 0.87 | 0.64 | 1.17 | 0.84 | 0.53 | 1.33 |
| No. of extranodal sites | ||||||
| 0-1 | Reference | |||||
| ≥2 | 0.75 | 0.51 | 1.12 | 0.90 | 0.52 | 1.57 |
| B-symptoms | ||||||
| Absent | Reference | |||||
| Present | 0.73 | 0.53 | 1.01 | 1.02 | 0.66 | 1.58 |
| Insurance Type | ||||||
| Private +/- M/M | Reference | |||||
| Medicaid | 1.08 | 0.62 | 1.86 | 1.23 | 0.58 | 2.63 |
| Medicare +/- Medicaid | 1.48 | 0.93 | 2.35 | 1.30 | 0.70 | 2.39 |
| Uninsured | 10.78* | 2.48 | 46.92 | 10.11* | 1.52 | 67.31 |
| Employed | ||||||
| No | Reference | |||||
| Yes | 0.67* | 0.45 | 0.99 | 0.83 | 0.50 | 1.40 |
| Diagnosis Era | ||||||
| 1992-1997 | Reference | |||||
| 1998-2002 | 24.67* | 7.62 | 79.82 | 25.50* | 7.78 | 83.57 |
| 2003-2010 | 174.67* | 53.82 | 566.90 | 153.23* | 46.12 | 509.06 |
*
Indicates statistical significance
Abbreviations: CI, Confidence Interval; ECOG, Eastern Cooperative Oncology Group; LDH, lactate dehydrogenase; ULN, upper limit of normal; M/M, Medicare/Medicaid.